The world is a complex system, and understanding it scientifically requires advanced computational resources and approaches. Engineers design the most powerful computers on Earth in order to model and simulate physical systems such as global climate, the expansion of the universe, and the behavior of matter at an atomic level. But today, high performance scientific computing means more than just supercomputers running numerical models, expanding to large-scale data analysis, AI and machine learning, visualization, and distributed and heterogeneous hardware systems.

UChicago CS researchers are changing the face of high performance computing (HPC), creating new computing paradigms at scale for understanding physical, biological, social, and ecological systems and answering the most significant questions facing society. Faculty lead efforts to apply the latest AI and data science approaches for scientific discovery, from computational imaging and spectroscopy to bioinformatics, neuroscience, and agriculture. In these areas, as well as in the development and application of new exascale systems such as Aurora, UChicago CS benefits from a strong partnership with Argonne National Laboratory.

Labs & Groups

Globus Labs

Ian Foster, Kyle Chard
Realizing a world in which all research data are reliably, rapidly, and securely accessible, discoverable, and usable.

Large-Scale Systems Group (LSSG)

Andrew A. Chien
Exploring critical systems research questions underlying sustainable, scalable large-scale systems, including cloud, high performance, edge, and mobile/IoT computing.

Chameleon

Kate Keahey, Haryadi Gunawi
A configurable experimental environment for large-scale edge to cloud research.

Center for Translational Data Science

Robert Grossman
A research center developing the discipline of translational data science and applying to advance biology, medicine, healthcare and environmental research.

Related Faculty

Kyle Chard

Kyle Chard

Research Associate Professor of Computer Science
Andrew A. Chien

Andrew A. Chien

William Eckhardt Distinguished Service Professor of Computer Science

Anshu Dubey

Senior Scientist, CASE Affiliate
Todd Dupont

Todd Dupont

Professor Emeritus of Computer Science, Mathematics, and the James Franck Institute
Ian Foster

Ian Foster

Arthur Holly Compton Distinguished Service Professor of Computer Science
Robert Grossman

Robert Grossman

Frederick H. Rawson Distinguished Service Professor in Medicine, Computer Science
Rana Hanocka

Rana Hanocka

Assistant Professor of Computer Science

Kate Keahey

Senior Scientist, CASE Affiliate
Gordon Kindlmann

Gordon Kindlmann

Associate Professor of Computer Science

Rick Stevens

Professor of Computer Science
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Rebecca Willett

Worah Family Professor in the Wallman Society of Fellows, Computer Science, Statistics, and the College

News & Events

UChicago CS News

Code with a Conscience: New CS Courses Tackle a Changing World

Sep 19, 2025
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UChicago CS News

Could Robots Help Kids Conquer Reading Anxiety? New Study from the Department of Computer Science at UChicago Suggests So

Sep 10, 2025
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UChicago CS News

University of Chicago Announces Next Phase of Quantum Supercomputer Initiative, Supported by NSF Grant

Sep 05, 2025
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UChicago CS News

NobleReach Scholar Bridges Tech and Public Service Through MSCAPP and AI Advisory Work

Sep 05, 2025
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UChicago CS News

A Bet Worth Placing: Computing and Data Science at UChicago

Sep 02, 2025
receiving the test of time award
UChicago CS News

UChicago Alum John Paparrizos Honored with SIGMOD Test-of-Time Award for Advancing Time Series Analytics

Aug 29, 2025
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UChicago CS News

University of Chicago Researchers Earn Top Honor for Adaptive Software Breakthrough

Aug 07, 2025
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UChicago CS News

Alumni Spotlight: Shama Tirukkala ‘24 is a Fulbright Finalist

Aug 07, 2025
data points
UChicago CS News

Finding the “Goldilocks” Solution to a Classic Math Problem: A Breakthrough in Numerical Integration

Jul 29, 2025
UChicago CS News

Ten Years of MSCAPP: Where Public Policy Meets Coding

Jul 25, 2025
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UChicago CS News

Moderation at the Crossroads: How Generative AI Platforms Manage Creativity and Content Safety

Jul 21, 2025
UChicago CS News

Can a Doctor’s Notes Reveal When They’re Tired? New Research Illuminates the Hidden Signals of Physician Fatigue—And Raises Questions About AI in Healthcare

Jul 17, 2025
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